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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/RN 1 dihydrochloride/4977/10/10 mg
产品编号:4977/10
市  场 价:¥3900.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$195.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/RN 1 dihydrochloride/4977/10/10 mg
商品介绍
Description:LSD1inhibitor
ChemicalName:1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanonedihydrochloride
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentlysinespecificdemethylase1(LSD1)inhibitor(IC50=70nM).ExhibitsselectivityforLSD1overMAO-AandMAO-B(IC50valuesare0.51and2.79μMforMAO-AandMAO-B,respectively).Impairslong-term,butnotshort-termmemoryinmice.BrainpenetrantfollowingsystemicadmiNISTration.

CompoundLibraries

RN1dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt452.42
FormulaC23H29N3O2.2HCl
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber1781835-13-9
PubChemID90488995
InChIKeyWMHAFZOOUBPQRX-VSIGASKDSA-N
SmilesO=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO9.0520mMwithgentlewarming
water9.0520

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight452.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.21mL11.05mL22.1mL
5mM0.44mL2.21mL4.42mL
10mM0.22mL1.11mL2.21mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet