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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Pyrimethamine/3918/50/50 mg
产品编号:3918/50
市  场 价:¥1300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$65.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Pyrimethamine/3918/50/50 mg
商品介绍
Description:Potentinhibitorofmultidrugandtoxinextrusion(MATE)transporters;alsoDHFRandSTAT3inhibitor
ChemicalName:5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofmultidrugandtoxinextrusion(MATE)transporters(Kivaluesare46and77nMforhumanMATE2-K-HEK293andMATE1-HEK293cellsrespectively).Alsoinhibitsdihydrofolatereductase(DHFR)andSTAT3.Decreasesproliferationofhumanautosomaldominantpolycystickidneydiseasecells.

CompoundLibraries

PyrimethamineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt248.71
FormulaC12H13ClN4
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber58-14-0
PubChemID4993
InChIKeyWKSAUQYGYAYLPV-UHFFFAOYSA-N
SmilesClC1=CC=C(C2=C(N)N=C(N)N=C2CC)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.87100
ethanol2.4910

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight248.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.02mL20.1mL40.21mL
5mM0.8mL4.02mL8.04mL
10mM0.4mL2.01mL4.02mL
50mM0.08mL0.4mL0.8mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet