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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Pyridostatin pentahydrochloride/4763/10/10 mg
产品编号:4763/10
市  场 价:¥4180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$209.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Pyridostatin pentahydrochloride/4763/10/10 mg
商品介绍
Description:StABIlizesG-quadruplexes;inducesDNAdamageandcellcyclearrest
ChemicalName:4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamidepentahydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

BindsandstabilizesG-quadruplexes,inducingDNAdamageandcellcyclearrest(Kd=490nM);targetstheproto-oncogeneSrc,reducingSrcproteinabundanceandSrc-dependentmotilityinhumanbreastcancercells.AlsotargetstelomericG-quadruplexes,inducingtelomerasedysfunction.ActivatestheDNA-dependentproteinkinasecatalyticsunbunit(DNA-PKcs).

TechnicalData

M.Wt778.94
FormulaC31H32N8O5.5HCl
StorageDesiccateatRT
Purity≥98%(HPLC)
PubChemID78243739
InChIKeySRIZPFGTXSQRFM-UHFFFAOYSA-N
SmilesNCCOC1=CC(C(NC2=NC(C=CC=C3)=C3C(OCCN)=C2)=O)=NC(C(NC4=CC(OCCN)=C(C=CC=C5)C5=N4)=O)=C1.Cl.Cl.Cl.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
water77.89100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight778.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.28mL6.42mL12.84mL
5mM0.26mL1.28mL2.57mL
10mM0.13mL0.64mL1.28mL
50mM0.03mL0.13mL0.26mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet