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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Plumbagin/4761/50/50 mg
产品编号:4761/50
市  场 价:¥980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$49.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Plumbagin/4761/50/50 mg
商品介绍
Description:InducesG2/Mcellcyclearrest;anticancer
ChemicalName:5-Hydroxy-2-methyl-1,4-naphthalenedione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Anticanceragent.InducesG2/McellcyclearrestandapoptosisinA549cellsthroughJNK-dependentp53Ser15phosphorylation;inhibitsA549andMDA-MD-231tumourxenograftgrowthinnudemice.PromotesautophagiccelldeathinMDA-MB-231andMCF-7cellsandinhibitsAkt/mTORsignaling.InducesintracellularROSgenerationinaPI5-kinase-dependentmanner.Alsoinhibitsp300-mediatedacetylationofp53.

TechnicalData

M.Wt188.18
FormulaC11H8O3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber481-42-5
PubChemID10205
InChIKeyVCMMXZQDRFWYSE-UHFFFAOYSA-N
SmilesCC2=CC(C1=C(C2=O)C=CC=C1O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO18.82100
ethanol9.4150

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight188.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM5.31mL26.57mL53.14mL
5mM1.06mL5.31mL10.63mL
10mM0.53mL2.66mL5.31mL
50mM0.11mL0.53mL1.06mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet