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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Pifithrin-μ/2653/10/10 mg
产品编号:2653/10
市  场 价:¥1780.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$89.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Pifithrin-μ/2653/10/10 mg
商品介绍
Description:Inhibitorofp53-mitochondrialbinding
AlternativeNames:NSC303580
ChemicalName:2-Phenylethynesulfonamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitsp53bindingtomitochondriabyreducingitsaffinityforantiapoptoticproteinsBcl-2andBcl-XL.Displaysnoeffectonthetransactivationalorcellcyclecheckpointcontrolfunctionofp53.Potentiallyincreasesreprogrammingefficiencyofhumansomaticcellstoinducedpluripotentstemcells(iPSCs)bysilencingp53.Reducescelldeathinducedbyγ-rADIationinvitroandprotectsmicefromdosesofradiationthatcauselethalhematopoieticsyndrome.Selectivelyinhibitsheatshockprotein70(HSP70)activity.

CompoundLibraries

Pifithrin-μisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt181.21
FormulaC8H7NO2S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber64984-31-2
PubChemID327653
InChIKeyZZUZYEMRHCMVTB-UHFFFAOYSA-N
SmilesNS(=O)(=O)C#CC1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO13.12100
ethanol13.12100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight181.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM5.52mL27.59mL55.18mL
5mM1.1mL5.52mL11.04mL
10mM0.55mL2.76mL5.52mL
50mM0.11mL0.55mL1.1mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet