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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PX 12/2954/50/50 mg
产品编号:2954/50
市  场 价:¥10100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$505.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PX 12/2954/50/50 mg
商品介绍
Description:Thioredoxin-1inhibitor
AlternativeNames:IV-2
ChemicalName:2-[(1-Methylpropyl)dithio]-1H-imidazole
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Thioredoxin-1(Trx-1)inhibitor;irreversIBLyinactivatesTrx-1asasubstrateforreductionbythioredoxinreductase(TR);competitivelyinhibitsthereductionofTrx-1byTR(Ki=30.8μM).AttenuatesexpressionofHIF-1α,VEGFandiNOS(IC50valuesare7.2,10.4and18.1μMrespectively).Exhibitsantitumoractivity;directlyinhibitstubulininvitroanddecreasestumormicrovesseldensityinvivo.

TechnicalData

M.Wt188.31
FormulaC7H12N2S2
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber141400-58-0
PubChemID219104
InChIKeyBPBPYQWMFCTCNG-UHFFFAOYSA-N
SmilesCC(CC)SSC1=NC=CN1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO18.83100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight188.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM5.31mL26.55mL53.1mL
5mM1.06mL5.31mL10.62mL
10mM0.53mL2.66mL5.31mL
50mM0.11mL0.53mL1.06mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet