请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PTIQ/4604/50/50 mg
产品编号:4604/50
市  场 价:¥13700.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$685.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PTIQ/4604/50/50 mg
商品介绍
Description:PotentMMP-3expressioninhibitor;neuroprotective
ChemicalName:1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofMMP-3expression(IC50=60nM);down-regulatesinductionofMMP-3inbothstresseddopaminergiccellsandactivatedmicroglia.AlsosuppressesproinflammatoryresponsesandinhibitsNOproductioninactivatedmicroglia.Attenuatesmotordeficits,preventsneurodegenerationandsuppressesmicroglialactivationinaParkinson'sdiseasemousemodel.Brainpenetrant.

TechnicalData

M.Wt235.28
FormulaC13H17NO3
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber1032822-42-6
PubChemID24812799
InChIKeyBEDYMEDICHGLSE-UHFFFAOYSA-N
SmilesO=C(CC)N2CC1=CC(O)=C(OC)C=C1CC2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.NaOH4.7120
DMSO23.53100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight235.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.25mL21.25mL42.5mL
5mM0.85mL4.25mL8.5mL
10mM0.43mL2.13mL4.25mL
50mM0.09mL0.43mL0.85mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet