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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PIT 1/4168/10/10 mg
产品编号:4168/10
市  场 价:¥3100.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$155.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PIT 1/4168/10/10 mg
商品介绍
Description:PIP3antagoNIST.BlocksPIP3-PHinteraction;inhibitsAktsignaling
ChemicalName:N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectivePIP3antagonist.BlocksthebindingofPIP3tothepleckstrinhomology(PH)domainofAkt(IC50=31.03μM).InhibitscancercellsurvivalandinducesapoptosisbyinhibitionofPIP3-dependentPI3-kinase/Aktsignaling.Exhibitsantitumoractivityinvivo.

TechnicalData

M.Wt351.76
FormulaC14H10ClN3O4S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber53501-41-0
PubChemID3664359
InChIKeyRIGXBXPAOGDDIG-UHFFFAOYSA-N
SmilesClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO26.3875
ethanol3.5210

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight351.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.84mL14.21mL28.43mL
5mM0.57mL2.84mL5.69mL
10mM0.28mL1.42mL2.84mL
50mM0.06mL0.28mL0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet