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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PFI 4/5576/10/10 mg
产品编号:5576/10
市  场 价:¥4180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$209.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PFI 4/5576/10/10 mg
商品介绍
Description:PotentandselectiveBRPF1bromodomaininhibitor
ChemicalName:N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveBRPF1bromodomaininhibitor(IC50=80nM).Exhibits>100-foldselectivityforBRPF1overapanelofotherbromodomainsincludingBRPF2(BRD1),BRPF3andBRD4.DisruptsBRPF1bindingtohistoneH3.3.Cellpermeable.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI4probesummaryontheSGCwebsite.

CompoundLibraries

PFI4isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt380.44
FormulaC21H24N4O3
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber900305-37-5
PubChemID40642506
InChIKeyQCIJLRJBZDBVDB-UHFFFAOYSA-N
SmilesCN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO19.0250
ethanol3.810

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight380.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.63mL13.14mL26.29mL
5mM0.53mL2.63mL5.26mL
10mM0.26mL1.31mL2.63mL
50mM0.05mL0.26mL0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet