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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PFI 1/4445/50/50 mg
产品编号:4445/50
市  场 价:¥15100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$755.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PFI 1/4445/50/50 mg
商品介绍
Description:BETbromodomaininhibitor
ChemicalName:2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentBETbromodomaininhibitor;exhibitsinhibitoryactivityatbromodomain-containingprotein(BRD)2andBRD4(IC50valuesare98and220nMrespectively).InducesapoptosisandG1cellcyclearrestinBETinhibitor-sensitivecelllines(MV4;11).AlsodownregulatesAuroraBexpressioninMV4;11cells.Cellpermeable.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI1probesummaryontheSGCwebsite.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofPFI1isreviewedonthechemicalprobeswebsite.

CompoundLibraries

PFI1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt347.39
FormulaC16H17N3O4S
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber1403764-72-6
PubChemID71271629
InChIKeyTXZPMHLMPKIUGK-UHFFFAOYSA-N
SmilesO=C2NC1=CC=C(NS(C3=CC=CC=C3OC)(=O)=O)C=C1CN2C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO17.3750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight347.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.88mL14.39mL28.79mL
5mM0.58mL2.88mL5.76mL
10mM0.29mL1.44mL2.88mL
50mM0.06mL0.29mL0.58mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet