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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PBIT/5930/50/50 mg
产品编号:5930/50
市  场 价:¥8900.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$445.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PBIT/5930/50/50 mg
商品介绍
Description:JARID1(JumonjiAT-RichInteractiveDomain1)inhibitor
ChemicalName:2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

JARID1(JumonjiAT-RichInteractiveDomain1)inhibitor(IC50valuesare3,4.9and6μMforJARID1B,1Aand1C,respectively).SelectiveforJARID1overUTXandJMJD3.IncreaseslevelsofmethylatedH3K4inJARIDB1-transfectedHeLacellsandMCF7cells.InhibitsproliferationofbreastcancercelllinesexpressinghighlevelsofJARIDB1.

TechnicalData

M.Wt241.31
FormulaC14H11NOS
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber2514-30-9
PubChemID935415
InChIKeyKRXMYBAZKJBJAB-UHFFFAOYSA-N
SmilesCC1=CC=C(N2SC3=C(C2=O)C=CC=C3)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.13100
ethanol4.8320

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight241.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.14mL20.72mL41.44mL
5mM0.83mL4.14mL8.29mL
10mM0.41mL2.07mL4.14mL
50mM0.08mL0.41mL0.83mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet