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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Nutlin 3a/6075/25/25 mg
产品编号:6075/25
市  场 价:¥15180.00
场      地:美国(厂家直采)
产品分类: 分子类>核酸酶类>连接酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$759.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Nutlin 3a/6075/25/25 mg
商品介绍
Description:MDM2antagoNIST;activeenantiomerofNutlin-3(Cat.No.3984)
ChemicalName:4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

MDM2antagonist(IC50=90nM);inhibitstheMDM2-p53interaction.ActiveenantiomerofNutlin-3(Cat.No.3984).InducesexpressionforP53regulatedgenes.Suppressestumorgrowthinvivo>98%inprostatecancerandosteosarcomacancermodels.Antiproliferative.

TechnicalData

M.Wt581.49
FormulaC30H30Cl2N4O4
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber675576-98-4
PubChemID11433190
InChIKeyBDUHCSBCVGXTJM-WUFINQPMSA-N
SmilesClC1=CC=C([C@H]2[C@H](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO58.15100
ethanol58.15100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight581.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.72mL8.6mL17.2mL
5mM0.34mL1.72mL3.44mL
10mM0.17mL0.86mL1.72mL
50mM0.03mL0.17mL0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet