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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/NVP BHG 712/4405/1/1 mg
产品编号:4405/1
市  场 价:¥2100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$105.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/NVP BHG 712/4405/1/1 mg
商品介绍
Description:PotentEphB4kinaseinhibitor
ChemicalName:4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamidetrifluoroacetate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveinhibitorofEphB4kinase;exhibitsselectivityforEphB4overmorethan40otherkinasesinvitro,includingFGFR3.InhibitsEphB4autophosphorylationintransientlytransfectedHEK293cells.AlsoinhibitsVEGF-inducedangiogenesisinvivo;thoughttoinhibitEphB4forwardsignaling.Orallyactive.

TechnicalData

M.Wt617.5
FormulaC26H20F3N7O.CF3CO2H
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber940310-85-0
PubChemID73332408
InChIKeyKCYJGZKWKFCVGC-UHFFFAOYSA-N
SmilesCN1N=CC2=C1N=C(C4=CC=CN=C4)N=C2NC3=CC(C(NC5=CC=CC(C(F)(F)F)=C5)=O)=CC=C3C.OC(C(F)(F)F)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.740

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight617.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.62mL8.1mL16.19mL
5mM0.32mL1.62mL3.24mL
10mM0.16mL0.81mL1.62mL
50mM0.03mL0.16mL0.32mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet