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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/NSC 663284/1867/10/10 mg
产品编号:1867/10
市  场 价:¥4500.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/NSC 663284/1867/10/10 mg
商品介绍
Description:Potent,selectiveCdc25phosphataseinhibitor
ChemicalName:6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,selectiveinhibitorofCdc25dualspecificityphosphatases(Kivaluesare29,95and89nMforhumanCdc25A,Cdc25B2andCdc25Crespectively);>20-and>450-foldselectiveoverVHRandPTP1Bphosphatasesrespectively.ArrestscellsatbothG1andG2/Mphaseandblockscdk2andcdk1activation.Blocksproliferationofarangeofhumantumorcelllines(IC50=0.2-35μM).

CompoundLibraries

NSC663284isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt321.76
FormulaC15H16ClN3O3
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber383907-43-5
PubChemID379077
InChIKeyBMKPVDQDJQWBPD-UHFFFAOYSA-N
SmilesClC1=C(NCCN2CCOCC2)C(=O)C2=NC=CC=C2C1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO16.150
ethanol16.150

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight321.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.11mL15.54mL31.08mL
5mM0.62mL3.11mL6.22mL
10mM0.31mL1.55mL3.11mL
50mM0.06mL0.31mL0.62mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet