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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/NSC 319726/5065/50/50 mg
产品编号:5065/50
市  场 价:¥14180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$709.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/NSC 319726/5065/50/50 mg
商品介绍
Description:Reactivatorofmutantp53
ChemicalName:1-Azetidinecarbothioicacid[1-(2-pyridinyl)ethylidene]hydrazide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Reactivatorofmutantp53.Restoreswildtypep53structureandfunctiontothep53R175mutant.Inhibitsgrowthoffibroblastsexpressingthep53R175mutation(IC50=8nM).Alsoinhibitsgrowthofxenografttumorsexpressingthep53R175mutationinvivo.

CompoundLibraries

NSC319726isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt234.32
FormulaC11H14N4S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber71555-25-4
PubChemID5351307
InChIKeyXDHBUMNIQRLHGO-UKTHLTGXSA-N
SmilesC/C(C1=NC=CC=C1)=NNC(N2CCC2)=S

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO23.43100
ethanol2.3410mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight234.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.27mL21.34mL42.68mL
5mM0.85mL4.27mL8.54mL
10mM0.43mL2.13mL4.27mL
50mM0.09mL0.43mL0.85mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet