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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/MRT 10/4585/50/50 mg
产品编号:4585/50
市  场 价:¥14180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$709.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/MRT 10/4585/50/50 mg
商品介绍
Description:Smoothened(Smo)antagoNIST
ChemicalName:N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide
Purity:≥98%
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Smoothened(Smo)receptorantagonist(IC50=0.5μMinHEK293cellstransientlyexpressingmouseSmo).InhibitsShhN-inducedGliluciferasereporteractivityinShh-light2cells(IC50=2.5μM);actsasaninverseagonistduringnontranscriptionalHedgehogpathwayactivation(IC50=2.5μMinHEK293cells).

TechnicalData

M.Wt465.52
FormulaC24H23N3O5S
StorageStoreat+4°C
Purity≥98%
CASNumber330829-30-6
PubChemID1139102
InChIKeyKVQVEZQDNHMQJV-UHFFFAOYSA-N
SmilesO=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO46.55100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight465.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.15mL10.74mL21.48mL
5mM0.43mL2.15mL4.3mL
10mM0.21mL1.07mL2.15mL
50mM0.04mL0.21mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet