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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Lyn peptide inhibitor/2265/1/1 mg
产品编号:2265/1
市  场 价:¥6380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$319.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Lyn peptide inhibitor/2265/1/1 mg
商品介绍
Description:InhibitsLyn-dependentactivitiesofIL-5receptor;cell-permeable
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Cell-permeableinhibitorofLyn-dependenteffectsoftheIL-5receptor.BlocksbindingofLyntyrosinekinasetoβcsubunitofIL-3/GM-CSF/IL-5receptors,blockingLynactivation.InhibitsIL-5receptor-mediatedeosinophildifferentiationandsurvivalinvitro.Inhibitsairwayeosinophilicinflammationinmousemodelofasthma.

TechnicalData

M.Wt2370.91
FormulaC115H184N30O24
SequenceYGYRLRRKWEEKIPNP

(Modifications:Tyr-1=Octadecanoyl-Tyr,Pro-16=C-terminalamide)

StorageDesiccateat-20°C
CASNumber222018-18-0
PubChemID90001265
InChIKeyMITSVNFZLBORMW-QMGLJYLZSA-N
SmilesCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto10mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight2370.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.42mL2.11mL4.22mL
5mM0.08mL0.42mL0.84mL
10mM0.04mL0.21mL0.42mL
50mM0.01mL0.04mL0.08mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet