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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/LH 846/4896/10/10 mg
产品编号:4896/10
市  场 价:¥3300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$165.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/LH 846/4896/10/10 mg
商品介绍
Description:Selectivecaseinkinase1δinhibitor
ChemicalName:N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveinhibitorofcaseinkinase(CK)1δ(IC50valuesare290nM,1.3μMand2.5μMforCK1δ,εandα);displaysnoinhibitoryactivityatCK2.InhibitsCK1δ-dependentphosphorylationanddegradationofPER1protein.ShowntolengthenthecircADIanperiodinU2OScells,withminimaleffectonamplitude.

CompoundLibraries

LH846isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt316.81
FormulaC16H13ClN2OS
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber639052-78-1
PubChemID851474
InChIKeyDYHAMRNAHTWYKY-UHFFFAOYSA-N
SmilesO=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.68100
ethanol1.585mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight316.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.16mL15.78mL31.56mL
5mM0.63mL3.16mL6.31mL
10mM0.32mL1.58mL3.16mL
50mM0.06mL0.32mL0.63mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet