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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ko 143/3241/10/10 mg
产品编号:3241/10
市  场 价:¥4980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$249.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ko 143/3241/10/10 mg
商品介绍
Description:PotentandselectiveBCRPinhibitor
ChemicalName:(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoicacid1,1-dimethylethylester
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivebreastcancerresistanceproteinmultidrugtransporter(BCRP)inhibitor(EC90=26nM).Displays>200-foldselectivityoverP-gpandMRP-1transporters.IncreasesintracellulardrugaccumulationandreversesBCRP-mediatedmultidrugresistance.InhibitsABCB1andABCC1athigherconcentrations.Rapidlymetabolizedinratplasma.

CompoundLibraries

Ko143isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt469.57
FormulaC26H35N3O5
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber461054-93-3
PubChemID10322450
InChIKeyNXNRAECHCJZNRF-JBACZVJFSA-N
SmilesO=C(N[C@H]4CCC(OC(C)(C)C)=O)[C@]3([H])CC1=C([C@H](CC(C)C)N3C4=O)NC2=C1C=CC(OC)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO23.4850
ethanol46.96100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight469.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.13mL10.65mL21.3mL
5mM0.43mL2.13mL4.26mL
10mM0.21mL1.06mL2.13mL
50mM0.04mL0.21mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet