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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/JW 67/4651/10/10 mg
产品编号:4651/10
市  场 价:¥2980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$149.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/JW 67/4651/10/10 mg
商品介绍
Description:Wntpathwayinhibitor;inducesdegradationofactiveβ-catenin
ChemicalName:Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofcanonicalWntpathwaysignaling(IC50=1.17μM);targetstheβ-catenindestructioncomplex(GSK-3β/AXIN/APC)toinduceβ-catenindegradation.SelectiveforthecanonicalWntpathwayovertheSonichedgehog(Shh)andNF-κBpathways.BlocksG1/Scellcycleprogressionincolorectalcancer(CRC)celllines(GI50=7.8μM).

CompoundLibraries

JW67isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt394.38
FormulaC21H18N2O6
StorageStoreat+4°C
Purity≥97%(HPLC)
CASNumber442644-28-2
PubChemID644733
InChIKeyBTXRSHKJNDFHGA-UHFFFAOYSA-N
SmilesO=C1NC6=C(C=CC=C6)C21OCC3(COC(C(NC5=C4C=CC=C5)=O)4OC3)CO2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO39.44100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight394.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.54mL12.68mL25.36mL
5mM0.51mL2.54mL5.07mL
10mM0.25mL1.27mL2.54mL
50mM0.05mL0.25mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet