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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/JIB 04/4972/50/50 mg
产品编号:4972/50
市  场 价:¥13300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$665.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/JIB 04/4972/50/50 mg
商品介绍
Description:PanJumonjiinhibitor;activeinvivo
ChemicalName:5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PanJumonjihistonedemethylaseinhibitor(IC50valuesare230,340,435,445,855and1100nMforJARID1A,JMJD2E,JMJD2B,JMJD2A,JMJD3andJMJD2Crespectively).ExhibitsnegligIBLeactivityatPHD2andTET1.SelectivelyblockscancercellgrowthinvitroanddiminishestumorgrowthinH358andA549mousexenograftmodelsinvivo.Prolongssurvivalinamousemodelofbreastcancer.

CompoundLibraries

JIB04isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt308.76
FormulaC17H13ClN4
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber199596-05-9
PubChemID6519698
InChIKeyYHHFKWKMXWRVTJ-OQKWZONESA-N
SmilesClC(C=C3)=CN=C3N/N=C(C2=CC=CC=C2)/C1=CC=CC=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO30.88100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight308.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.24mL16.19mL32.39mL
5mM0.65mL3.24mL6.48mL
10mM0.32mL1.62mL3.24mL
50mM0.06mL0.32mL0.65mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet