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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Indibulin/3728/10/10 mg
产品编号:3728/10
市  场 价:¥3180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$159.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Indibulin/3728/10/10 mg
商品介绍
Description:MicrotubuledestABIlizer
AlternativeNames:D24851
ChemicalName:2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Microtubuledestabilizerthatblockstubulinpolymerization(IC50=0.3μM).Blockscellcycleprogressionatmetaphaseanddisplaysantitumoractivityagainstavarietyofmalignanciesinvitro(IC50valuesrangingfrom0.036-0.285μM).InducescompletetumorremissionintheYoshidaAH13ratsarcomamodelinvivo.Lacksneurotoxicityduetoanabilitytodiscriminatebetweenposttranslationallymodifiedtubulininmatureneuronalmicrotubulesandless-modifiedtubulinpresentinimmatureneuronalornonneuronalmicrotubules.DisplaysoralavailabilityandefficacytowardsMDRtumorcells.

TechnicalData

M.Wt389.83
FormulaC22H16ClN3O2
StorageDesiccateat-20°C
Purity≥98%(HPLC)
CASNumber204205-90-3
PubChemID2929
InChIKeySOLIIYNRSAWTSQ-UHFFFAOYSA-N
SmilesClC(C=C3)=CC=C3CN2C1=CC=CC=C1C(C(C(NC4=CC=NC=C4)=O)=O)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO9.7525

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight389.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.57mL12.83mL25.65mL
5mM0.51mL2.57mL5.13mL
10mM0.26mL1.28mL2.57mL
50mM0.05mL0.26mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet