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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/IOX 1/4464/50/50 mg
产品编号:4464/50
市  场 价:¥14180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$709.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/IOX 1/4464/50/50 mg
商品介绍
Description:Histonedemethylaseinhibitor;cellpermeable
AlternativeNames:5-carboxy-8HQ
ChemicalName:8-Hydroxy-5-quinolinecarboxylicacid
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HistonedemethylaseJMJDinhibitor(IC50valuesare0.12,0.17,0.2,0.3,0.6and1μMforJMJD3,JMJD1A,JMJD2A,JMJD2E,JMJD2CandUTXrespectively).Cellpermeable;inhibitsJMJD2A-mediatedH3K9me3demethylationinHeLacells.

LicensingInformation

ThiscompoundissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheIOX1summaryontheSGCwebsite.

CompoundLibraries

IOX1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt189.17
FormulaC10H7NO3
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber5852-78-8
PubChemID459617
InChIKeyJGRPKOGHYBAVMW-UHFFFAOYSA-N
SmilesOC2=CC=C(C(O)=O)C1=CC=CN=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.NaOH18.92100
DMSO18.92100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight189.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM5.29mL26.43mL52.86mL
5mM1.06mL5.29mL10.57mL
10mM0.53mL2.64mL5.29mL
50mM0.11mL0.53mL1.06mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet