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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/HA14-1/1541/50/50 mg
产品编号:1541/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/HA14-1/1541/50/50 mg
商品介绍
Description:Bcl-2inhibitor.Inducesapoptosis
ChemicalName:2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Cell-permeableinhibitorofBcl-2protein(IC50~9μM);actsbybindingtothesurfacepocket.DisruptsBax/Bcl-2interactionandinducesapoptosisoftumorcells.AlsobindstotheantiapoptoticBlc-2proteinsBcl-XLandBcl-w.

TechnicalData

M.Wt409.23
FormulaC17H17BrN2O5
StorageDesiccateat-20°C
CASNumber65673-63-4
PubChemID3549
InChIKeySXJDCULZDFWMJC-UHFFFAOYSA-N
SmilesCCOC(=O)C(C#N)C1C2=C(OC(N)=C1C(=O)OCC)C=CC(Br)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.92100
ethanol40.92100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight409.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.44mL12.22mL24.44mL
5mM0.49mL2.44mL4.89mL
10mM0.24mL1.22mL2.44mL
50mM0.05mL0.24mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet