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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Z-Guggulsterone/3570/10/10 mg
产品编号:3570/10
市  场 价:¥3980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Z-Guggulsterone/3570/10/10 mg
商品介绍
Description:Broadspectrumsteroidreceptorligand.Moreactiveisomerofguggulsterone(Cat.No.2013)
ChemicalName:(Z)-Pregna-4,17(20)-diene-3,16-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Broadspectrumsteroidreceptorligand;mineralocorticoid,progesteroneandglucocorticoidreceptorantagoNIST(Kivaluesare37,224and252nMrespectively)andweakandrogenreceptoragonist(Ki=315nM).InducesapoptosisinprostatecancercellsandinhibitsangiogenesisviasuppressionoftheVEGF-VEGFR2-Aktsignalingpathway.ExhibitsantilipidemicactivityviaantagonismofthefarnesoidXreceptor(FXR)anddisplaysantiseptic,antirheumaticandanti-inflammatoryactivityinvivo.Moreactiveisomerofguggulsterone(Cat.No.2013).

TechnicalData

M.Wt312.45
FormulaC21H28O2
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber39025-23-5
PubChemID6450278
InChIKeyWDXRGPWQVHZTQJ-OSJVMJFVSA-N
SmilesO=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2CC[C@@]/4(C)[C@]([H])3CC(C4=C/C)=O)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO6.2520mMwithgentlewarming
ethanol3.1210mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight312.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.2mL16mL32.01mL
5mM0.64mL3.2mL6.4mL
10mM0.32mL1.6mL3.2mL
50mM0.06mL0.32mL0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet