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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Guggulsterone/2013/50/50 mg
产品编号:2013/50
市  场 价:¥13300.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$665.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Guggulsterone/2013/50/50 mg
商品介绍
Description:Broadspectrumsteroidreceptorligand.AntagonizesFXRanddisplayshypolipidemicactivity
ChemicalName:Pregna-4,17(20)-diene-3,16-dione
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Broadspectrumsteroidreceptorligand;bindswithhighaffinitytomineralocorticoidreceptors(Ki=39nM)andloweraffinitytoprogesterone,androgenandglucocorticoidreceptors(Kivaluesare201,240and224nMrespectively).FunctionsprimarilyasanantagoNISTofthesereceptors,withtheexceptionoftheprogesteronereceptorwhereitdisplayspartialagonisteffects.Alsoexertshypolipidemicactivity,likelyviaantagonismofthereceptorforbileacids(farnesoidXreceptor;FXR).

TechnicalData

M.Wt312.45
FormulaC21H28O2
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber95975-55-6
PubChemID146898
InChIKeyWDXRGPWQVHZTQJ-NRJJLHBYSA-N
Smiles[H][C@@]12CC(=O)C(=CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
ethanol3.1210mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight312.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.2mL16mL32.01mL
5mM0.64mL3.2mL6.4mL
10mM0.32mL1.6mL3.2mL
50mM0.06mL0.32mL0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet