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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GSK 2830371/5140/10/10 mg
产品编号:5140/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GSK 2830371/5140/10/10 mg
商品介绍
Description:PotentandselectiveallostericinhibitorofWip1phosphatase
ChemicalName:5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveallostericinhibitorofWip1phosphatase(IC50=6nM).ExhibitsselectivityforWip1over21otherphosphatases.IncreasesphosphorylationofWip1substrates,includingp53,Chk2,H2AXandATM.Attenuatestumorcellgrowthinavarietyoflymphoidcelllines.Alsoinhibitslymphomaxenograftgrowthinvivo.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesonlyunderagreementfromGlaxoSmithKline

CompoundLibraries

GSK2830371isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt461.02
FormulaC23H29ClN4O2S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1404456-53-6
PubChemID70983932
InChIKeyIVDUVEGCMXCMSO-FQEVSTJZSA-N
SmilesClC1=CC(NCC2=CC=C(C(N[C@H]([C@@](NC4CC4)=O)CC3CCCC3)=O)S2)=C(C)N=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO46.1100
ethanol23.0550

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight461.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.17mL10.85mL21.69mL
5mM0.43mL2.17mL4.34mL
10mM0.22mL1.08mL2.17mL
50mM0.04mL0.22mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet