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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GC 1/4554/10/10 mg
产品编号:4554/10
市  场 价:¥3380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$169.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GC 1/4554/10/10 mg
商品介绍
Description:Highaffinitythyroidreceptorα(TRα)andTRβagoNIST;thyromimetic
AlternativeNames:Sobetirome
ChemicalName:2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]aceticacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Thyromimetic;highaffinityagonistatthyroidhormonereceptor(TR)βandTRαreceptors(KDvaluesare67and440pMrespectively).Displays5-and100-foldgreaterpotencythantheendogenousagonistT3invitroatTRα1andTRβ1receptorsrespectively.Promotesreversecholesteroltransportinchow-andfat-fedmice.Inducesproliferationofhepatocytesandpancreaticacinarcellsinratsindependentofpriortissueinjury.

CompoundLibraries

GC1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt328.4
FormulaC20H24O4
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber211110-63-3
PubChemID9862248
InChIKeyQNAZTOHXCZPOSA-UHFFFAOYSA-N
SmilesCC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO32.84100
ethanol32.84100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight328.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.05mL15.23mL30.45mL
5mM0.61mL3.05mL6.09mL
10mM0.3mL1.52mL3.05mL
50mM0.06mL0.3mL0.61mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet