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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Fluticasone propionate/2007/10/10 mg
产品编号:2007/10
市  场 价:¥3380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$169.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Fluticasone propionate/2007/10/10 mg
商品介绍
Description:SelectivehighaffinityglucocorticoidreceptoragoNIST
ChemicalName:(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioicacidfluoromethylester
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highaffinity,selectiveglucocorticoidreceptoragonist(Kd=0.5nM).Potentlystimulatesglucocorticoidreceptor-mediatedtransactivationofgeneexpressionandenhanceshumaneosinophilapoptosis(EC50=3.7nM)invitro.Inhibitsmastcellaccumulationinnasalmucosafollowingtopicaladministration.Lipophilicanti-inflammatoryagentwithloworalbioavailABIlity.AlsopotentiatesKV1channels(EC50=37nM).

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

FluticasonepropionateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt500.57
FormulaC25H31F3O5S
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber80474-14-2
PubChemID444036
InChIKeyWMWTYOKRWGGJOA-CENSZEJFSA-N
SmilesO=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO25.0350

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight500.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2mL9.99mL19.98mL
5mM0.4mL2mL4mL
10mM0.2mL1mL2mL
50mM0.04mL0.2mL0.4mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet