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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/FTY 720/6176/10/10 mg
产品编号:6176/10
市  场 价:¥1700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$85.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/FTY 720/6176/10/10 mg
商品介绍
Description:PotentS1PreceptoragoNIST;alsoimmunosuppressant
AlternativeNames:Fingolimod,Gilenya
ChemicalName:2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diolhydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

S1Preceptoragonist;undergoesphosphorylationbysphingosinekinase2,whichthenbindsS1P1,3,4and5receptors(EC50valuesare0.3-0.6nMforS1P1,4and5and~3nMforS1P3).Immunosuppresant;sequesterslymphocytesinlymphnodes,reducingautoimmuneresponse.SuppressesthedevelopmentofEAE(aninvivomodelofMS).Orallybioavailableandblood-brainbarrierpermeable.

CompoundLibraries

FTY720isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt343.93
FormulaC19H33NO2.HCl
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber162359-56-0
PubChemID107969
InChIKeySWZTYAVBMYWFGS-UHFFFAOYSA-N
SmilesCCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
water34.39100
DMSO34.39100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight343.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.91mL14.54mL29.08mL
5mM0.58mL2.91mL5.82mL
10mM0.29mL1.45mL2.91mL
50mM0.06mL0.29mL0.58mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet