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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/FK 506/3631/10/10 mg
产品编号:3631/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/FK 506/3631/10/10 mg
商品介绍
Description:Potentcalcineurininhibitor;immunosuppressant
AlternativeNames:Tacrolimus,Fujimycin
ChemicalName:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentcalcineurin(proteinphosphatase2B)inhibitorthatrequiresFK506-bindingprotein12(FKBP12)foractivity(IC50=3nM).InhibitssecretionofIL-1,IL-2(IC50=1nM),IL-3,IL-4,IL-6(IC50=35nM),GM-CSF,TNFα(IC50=10nM),IFNγandMycfromactivatedTcellsinvitro.Exhibitspotentimmunosuppressive,neuroprotectiveandanticonvulsantactivityinvivo.Analog(ascomycin,Cat.No.4210)alsoavailable.

TechnicalData

M.Wt804.02
FormulaC44H69NO12
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber104987-11-3
PubChemID445643
InChIKeyQJJXYPPXXYFBGM-LFZNUXCKSA-N
SmilesO[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO80.4100
ethanol80.4100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight804.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.24mL6.22mL12.44mL
5mM0.25mL1.24mL2.49mL
10mM0.12mL0.62mL1.24mL
50mM0.02mL0.12mL0.25mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet