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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Epothilone B/3502/100U/100 ug
产品编号:3502/100U
市  场 价:¥6180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$309.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Epothilone B/3502/100U/100 ug
商品介绍
Description:MicrotubulestABIlizationagent;promotestubulinpolymerization
AlternativeNames:Patupilone
ChemicalName:(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

MicrotubulestabilizationagentthatpromotestubulinpolymerizationandinducesG2-Mcellcyclearrest(EC50=32nMinHeLacells).Inhibitsproliferationofhumancarcinomacelllinesinvitro,includingMDRcellsoverexpressingtheP-glycoproteineffluxpump.ExhibitspotentcytotoxicityinMCF-7andA549cells(EC50valuesare0.3and2.7nMrespectively).InhibitsgrowthofHCT-15tumorsinmiceinvivo.

TechnicalData

M.Wt507.68
FormulaC27H41NO6S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber152044-54-7
PubChemID448013
InChIKeyQXRSDHAAWVKZLJ-PVYNADRNSA-N
SmilesCC1=NC(/C=[C@](C)/[C@@H](OC2=O)C[C@H]3[C@@](O3)(C)CCC[C@H](C)[C@H](O)[C@H](C([C@@](C)(C)[C@@H](O)C2)=O)C)=CS1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO5.0810

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight507.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.97mL9.85mL19.7mL
5mM0.39mL1.97mL3.94mL
10mM0.2mL0.98mL1.97mL
50mM0.04mL0.2mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet