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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ERK5-IN-1/5393/10/10 mg
产品编号:5393/10
市  场 价:¥4900.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$245.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ERK5-IN-1/5393/10/10 mg
商品介绍
Description:PotentandselectiveERK5inhibitor
ChemicalName:11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveERK5inhibitor;inhibitsEGFR-inducedERK5autophosphorylation(EC50=90nM)andERK5enzymaticactivity(IC50=162nM).Exhibitsatleast30-foldselectivityforERK5overLRRK2inacellbasedassay.AlsoselectiveforERK5overapanelofotherkinases.Orallybioavailable.

LicensingInformation

SoldunderlicensefromDana-FarberCancerInstitute.

CompoundLibraries

ERK5-IN-1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt638.8
FormulaC36H46N8O3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1435488-37-1
PubChemID71604307
InChIKeyXVBGRTMNFNMINE-UHFFFAOYSA-N
SmilesO=C2N(C)C3=C(N=C(NC5=CC=C(C(N6CCC(N7CCN(C)CC7)CC6)=O)C=C5OCC)N=C3)N(C4CCCC4)C1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO63.88100
ethanol63.88100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight638.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.57mL7.83mL15.65mL
5mM0.31mL1.57mL3.13mL
10mM0.16mL0.78mL1.57mL
50mM0.03mL0.16mL0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet