请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/COG 133/3405/1/1 mg
产品编号:3405/1
市  场 价:¥4180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$209.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/COG 133/3405/1/1 mg
商品介绍
Description:ApoEpeptidefragment
AlternativeNames:apoE(133-149)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Apolipoprotein(ApoE)peptidefragmentthatfunctionsviathelow-densitylipoproteinreceptor-relatedprotein(LRP).Substantiallyreducesthesymptomsofexperimentalautoimmuneencephalomyelitis,amodelofhumanmultiplesclerosis,andsuppressesinflammation,demyelinationandinfiltrationofcellsintothespinalcord.Alsoactsasanon-competitiveantagoNISTatα7nicotinicacetylcholinereceptors(IC50=445nM).

TechnicalData

M.Wt2169.73
FormulaC97H181N37O19
SequenceLRVRLASHLRKLRKRLL

(Modifications:Leu-1=N-terminalAc,Leu-17=C-terminalamide)

StorageStoreat-20°C
CASNumber514200-66-9
PubChemID16201427
InChIKeyQTWXJKVJIKDSLC-KIZXDXQLSA-N
SmilesCC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight2169.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.46mL2.3mL4.61mL
5mM0.09mL0.46mL0.92mL
10mM0.05mL0.23mL0.46mL
50mM0.01mL0.05mL0.09mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet