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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/CH 223191/3858/10/10 mg
产品编号:3858/10
市  场 价:¥3100.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$155.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/CH 223191/3858/10/10 mg
商品介绍
Description:Potentarylhydrocarbonreceptor(AhR)antagoNIST
ChemicalName:1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentarylhydrocarbonreceptor(AhR)antagonist(IC50=30nM).ExhibitsnoAhRagonist-likeactivity(atconcentrationsupto100μM).Inhibits2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)-inducedAhR-dependenttranscriptioninvitroandreducesTCDD-inducedtoxicityinvivo.AttenuatesTh17differentiationofnaiveCD4Tcellsandpromotesexpansionofhematopoieticstemcellsinvitro.

CompoundLibraries

CH223191isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt333.39
FormulaC19H19N5O
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber301326-22-7
PubChemID3091786
InChIKeyLKTNEXPODAWWFM-UHFFFAOYSA-N
SmilesCC1=C(/N=N/C2=CC=C(NC(C3=CC=NN3C)=O)C(C)=C2)C=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO33.34100
ethanol3.3310

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight333.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3mL15mL29.99mL
5mM0.6mL3mL6mL
10mM0.3mL1.5mL3mL
50mM0.06mL0.3mL0.6mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet