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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Bay 11-7085/1743/10/10 mg
产品编号:1743/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Bay 11-7085/1743/10/10 mg
商品介绍
Description:IrreversIBLeinhibitorofTNF-α-inducedIκBαphosphorylation
AlternativeNames:Bay11-7083
ChemicalName:(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

IrreversibleinhibitorofTNF-α-stimulatedIκBαphosphorylation(IC50~10μM);leadstodecreasedNF-κBandsubsequentdecreasedexpressionofadhesionmolecules.AlsoreversiblyactivatesMAPkinasesandstimulatesapoptosis.Anti-inflammatoryinvivo.

TechnicalData

M.Wt249.33
FormulaC13H15NO2S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber196309-76-9
PubChemID5353432
InChIKeyVHKZGNPOHPFPER-ONNFQVAWSA-N
SmilesCC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.93100
ethanol24.93100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight249.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.01mL20.05mL40.11mL
5mM0.8mL4.01mL8.02mL
10mM0.4mL2.01mL4.01mL
50mM0.08mL0.4mL0.8mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet