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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/BVT 948/2176/50/50 mg
产品编号:2176/50
市  场 价:¥12580.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$629.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/BVT 948/2176/50/50 mg
商品介绍
Description:Non-competitiveproteintyrosinephosphataseinhibitor;enhancesinsulinsignaling
ChemicalName:4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Non-competitive,cell-permeableinhibitorofproteintyrosinephosphatases(PTPs)(IC50=0.09-1.7μM);displaysirreversIBLeinhibitionthroughcatalysisofthehydrogenperoxide-dependentoxidationofPTP.Enhancesinsulinsignalinginvitroandinsulintoleranceinob/obmiceinvivo.AlsoinhibitsseveralcytochromeP450isoforms(IC50<10μM).

CompoundLibraries

BVT948isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt241.25
FormulaC14H11NO3
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber39674-97-0
PubChemID6604934
InChIKeyLLPBUXODFQZPFH-UHFFFAOYSA-N
SmilesCC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO12.0650
ethanol12.0650

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight241.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.15mL20.73mL41.45mL
5mM0.83mL4.15mL8.29mL
10mM0.41mL2.07mL4.15mL
50mM0.08mL0.41mL0.83mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet