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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/BDS I/5184/10U/10 ug
产品编号:5184/10U
市  场 价:¥2580.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$129.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/BDS I/5184/10U/10 ug
商品介绍
Description:PotentandreversIBLeKv3.4potassiumchannelblocker;neuroprotective
AlternativeNames:Blooddepressingsubstance1
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandreversibleKv3.4potassiumchannelblocker(IC50=47nM);alsoattenuatesinactivationofsodiumcurrentsbyactingonNav1.7andNav1.3channels.EnhancesTTX-sensitivesodiumcurrentsinratsmalldorsalrootganglionneurons.Neuroprotective.

TechnicalData

M.Wt4708.37
FormulaC210H297N57O56S6
SequenceAAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH

(Modifications:Disulfidebridge:4-39,6-32,22-40)

StorageStoreat-20°C
PubChemID90489021
InChIKeyNHDQBZJQNKDJOQ-UHFFFAOYSA-N
Smiles[H]N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC1=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N3)[C@@H](C)CC

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4708.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.21mL1.06mL2.12mL
5mM0.04mL0.21mL0.42mL
10mM0.02mL0.11mL0.21mL
50mM0mL0.02mL0.04mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet