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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/BAG 956/3606/50/50 mg
产品编号:3606/50
市  场 价:¥19300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$965.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/BAG 956/3606/50/50 mg
商品介绍
Description:DualPI3-kinaseandPDPK1(PDK1)inhibitor
ChemicalName:α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DualPDPK1(PDK1)andclassIPI3-Kinhibitor(IC50valuesare245,56,446,35and117nMforPDPK1andPI3-Kp110-α,-β,-δ,and-γrespectively).InhibitscellularAKTphosphorylationatThr308.Blockscellproliferation,causingarrestinG1phaseofthecellcycle.Slowstumorprogressioninmousexenograftmodels.

CompoundLibraries

BAG956isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt427.5
FormulaC28H21N5
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber853910-02-8
PubChemID24882589
InChIKeyGVPAGJWVBUZHNQ-UHFFFAOYSA-N
SmilesCC3=NC1=C(N3C4=CC=C(C(C)(C#N)C)C=C4)C2=C(C=CC(C#CC5=CN=CC=C5)=C2)N=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO17.140
ethanol8.5520

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight427.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.34mL11.7mL23.39mL
5mM0.47mL2.34mL4.68mL
10mM0.23mL1.17mL2.34mL
50mM0.05mL0.23mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet