请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Atorvastatin hemicalcium salt/3776/10/10 mg
产品编号:3776/10
市  场 价:¥2180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$109.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Atorvastatin hemicalcium salt/3776/10/10 mg
商品介绍
Description:PotentHMG-CoAreductaseinhibitor
AlternativeNames:Lipitor
ChemicalName:(R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoicacidhemicalciumsalt
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentHMG-CoAreductaseinhibitor(IC50=8nM).ReducescirculatingLDL-CbyinhibitingcholesterolbiosynthesisandinducingexpressionofLDLreceptors.Inhibitssmoothmusclecellproliferationinvitroandexhibitsantinociceptiveeffectsintheinflammatoryhypernociceptionmodel.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

AtorvastatinhemicalciumsaltisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt577.67
FormulaC33H34FN2O5.½Ca
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber134523-03-8
PubChemID60822
InChIKeyFQCKMBLVYCEXJB-MNSAWQCASA-L
Smiles[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO57.77100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight577.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.73mL8.66mL17.31mL
5mM0.35mL1.73mL3.46mL
10mM0.17mL0.87mL1.73mL
50mM0.03mL0.17mL0.35mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet