请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Astemizole/3489/50/50 mg
产品编号:3489/50
市  场 价:¥1500.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$75.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Astemizole/3489/50/50 mg
商品介绍
Description:Orallyactive,potentH1antagoNIST.AlsoKV11.1(hERG)channelblocker.
AlternativeNames:Hismanal
ChemicalName:1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Orallyactive,potenthistamineH1antagonist(IC50=4nM)thatdisplays20-fold,>250-foldand>250-foldselectivityover5-HT,dopamineandmuscarinicacetylcholinereceptorsrespectively.Exhibitsantimalarialactivityinmultidrugresistantstrainsinvitro(IC50=227-734nM).AlsopotentKV11.1(hERG)channelblocker(IC50=0.9nM)thatdisplayscardiotoxicityinvivo.

CompoundLibraries

AstemizoleisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt458.57
FormulaC28H31FN4O
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber68844-77-9
PubChemID2247
InChIKeyGXDALQBWZGODGZ-UHFFFAOYSA-N
SmilesFC(C=C5)=CC=C5CN2C1=CC=CC=C1N=C2NC3CCN(CCC4=CC=C(OC)C=C4)CC3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO45.86100
ethanol11.4625

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight458.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.18mL10.9mL21.81mL
5mM0.44mL2.18mL4.36mL
10mM0.22mL1.09mL2.18mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet