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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Amlexanox/4857/50/50 mg
产品编号:4857/50
市  场 价:¥6900.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Amlexanox/4857/50/50 mg
商品介绍
Description:InhibitorofTBK1andIKKε;antiallergicagent
ChemicalName:2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylicacid
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveinhibitorofTANK-bindingkinase1(TBK1)andIKKε(IC50valuesare~1-2μM).DisplaysnoeffectonIKKαorIKKβattheseconcentrations.ReversIBLylowersweight,increasesinsulinsensitivity,andreducesinflammationandsteatosisinthreemousemodelsofobesity.Exhibitsantiallergicactivity;inhibitsthereleaseofhistaminefromratmastcells.AlsobindstoHsp90andinhibitsC-terminalchaperoneactivityinvitro.

CompoundLibraries

AmlexanoxisalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt298.29
FormulaC16H14N2O4
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber68302-57-8
PubChemID2161
InChIKeySGRYPYWGNKJSDL-UHFFFAOYSA-N
SmilesCC(C)C1=CC=C2C(C(C(C=C(C(O)=O)C(N)=N3)=C3O2)=O)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO29.83100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight298.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.35mL16.76mL33.52mL
5mM0.67mL3.35mL6.7mL
10mM0.34mL1.68mL3.35mL
50mM0.07mL0.34mL0.67mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet