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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/VH 298/6156/10/10 mg
产品编号:6156
市  场 价:¥4900.00
场      地:美国(厂家直采)
产品分类: 分子类>核酸酶类>连接酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$245.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/VH 298/6156/10/10 mg
商品介绍
Description:High-affinityinhibitorofVHL
ChemicalName:(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

High-affinityinhibitorofE3ubiquitinligaseVHL(Kd=80-90nM).BlocksinteractionbetweenVHLandHIF-αdownstreamofHIF-αhydroxylation,initiatinghypoxicresponse.Resultsintime-andconcentration-dependentaccumulationofhydroxylatedHIF-α,andupregulatesmRNAandproteinlevelsofHIFtargetgenes.Cellpermeable.NegativecontrolcisVH298alsoavailable.

LicensingInformation

SoldunderlicencefromtheUniversityofDundee

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofVH298isreviewedontheChemicalProbeswebsite.

TechnicalData

M.Wt523.65
FormulaC27H33N5O4S
StorageStoreat-20°C
Purity≥98%(HPLC)
PubChemID122199236
InChIKeyNDVQUNZCNAMROD-RZUBCFFCSA-N
SmilesO=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)C4(C#N)CC4

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO52.37100
ethanol52.37100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight523.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.91mL9.55mL19.1mL
5mM0.38mL1.91mL3.82mL
10mM0.19mL0.95mL1.91mL
50mM0.04mL0.19mL0.38mL