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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/LDN 212854/6151/10/10 mg
产品编号:6151
市  场 价:¥3780.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$189.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/LDN 212854/6151/10/10 mg
商品介绍
Description:PotentbonemorphogeneticproteintypeI(ALK)inhibitor
ChemicalName:5-(6-(4-(1-Piperazinyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentALKinhibitor(IC50valuesare1.3,2.4,85.8,2,133and9,276nMforALK2,ALK1,ALK3,ALK4andALK5,respectively).ExhibitsselectivityforALK2overALK4andALK5incellularassays.InhibitsheterotopicossificationinamutantALK2mousemodeloffibrodysplasiaossificansprogressiva.AlsoexhibitsactivityagainstRIPK2,ABL1andPDGFR-β(IC50values<100nM).

LicensingInformation

SoldforresearchpurposesunderexclusiveagreementfromTheBrighamandWomen"sHospitalInc.USpatent14/776,302

TechnicalData

M.Wt406.48
FormulaC25H22N6
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1432597-26-6
PubChemID60182388
InChIKeyBBDGBGOVJPEFBT-UHFFFAOYSA-N
SmilesN1(C2=CC=C(C3=CN4N=CC(C5=CC=CC6=C5C=CC=N6)=C4N=C3)C=C2)CCNCC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
2eq.HCl20.3250
DMSO1.022.5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight406.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.46mL12.3mL24.6mL
5mM0.49mL2.46mL4.92mL
10mM0.25mL1.23mL2.46mL
50mM0.05mL0.25mL0.49mL