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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AZ PFKFB3 26/5675/10/10 mg
产品编号:5675
市  场 价:¥2580.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$129.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AZ PFKFB3 26/5675/10/10 mg
商品介绍
Description:PotentandselectivePFKFB3inhibitor
ChemicalName:(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectivePFKFB3inhibitor(IC50=0.023μM).SelectiveforPFKFB3overPFKFB2andPFKFB1isoforms(IC50valuesare0.382μMand2.06μM,respectively).Reduceslevelsoffructose-1,6-bisphosphateinA549cells(IC50=0.343μM).Exhibitsnosignificantinhibitionofotherkinases.

TechnicalData

M.Wt402.49
FormulaC24H26N4O2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1704740-52-2
PubChemID118735769
InChIKeyOOGHGWKBJXQNEJ-QFIPXVFZSA-N
SmilesN#CC1=CN(CC(C)C)C2=C1C=C(OC3=CC=C(NC([C@H]4NCCC4)=O)C=C3)C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.25100
ethanol40.25100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight402.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.48mL12.42mL24.85mL
5mM0.5mL2.48mL4.97mL
10mM0.25mL1.24mL2.48mL
50mM0.05mL0.25mL0.5mL