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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/D9/5921/10/10 mg
产品编号:5921
市  场 价:¥1980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$99.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/D9/5921/10/10 mg
商品介绍
Description:Potentthioredoxinreductase(TrxR)inhibitor
ChemicalName:(Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentthioredoxinreductase(TrxR)inhibitor(EC50=2.8nM,IC50=0.03and0.1μMinMCF-7cellsandHT-29cells,respectively).Highlystableinvivo;exhibitsnosignificantligandexchangewithalbumin.Inhibitstumorproliferationinvitroandinvivobyinducingcelldeath.Selectivelykillscancercells.

TechnicalData

M.Wt596.43
FormulaC25H20AuOPS
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1527513-89-8
PubChemID127021039
InChIKeyDROLHVHTLXUINH-UHFFFAOYSA-O
Smiles[Au].COC1=CC=C(C=C1)C#C.S1C=CC=C1P(C1=CC=CC=C1)C1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO59.64100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight596.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.68mL8.38mL16.77mL
5mM0.34mL1.68mL3.35mL
10mM0.17mL0.84mL1.68mL
50mM0.03mL0.17mL0.34mL