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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SR 10067/6038/10/10 mg
产品编号:6038
市  场 价:¥2980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$149.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SR 10067/6038/10/10 mg
商品介绍
Description:SelectiveRev-Erbα/βagoNIST;anxiolytic
ChemicalName:[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveRev-Erbα/βagonist(IC50valuesare160and170nMforRev-ErbβandRev-Erbαrespectively).Exhibitsnosignificantactivityagainstawiderangeofnuclearreceptors,otherreceptors,ionchannelsandtransportersat20μM.Increaseswakefulness,reducesREMandslowwavesleepinvivo.Alsoreducesanxiety-likebehaviorinmarble-buryingassay.Cellpermeableandbrainpenetrant.

TechnicalData

M.Wt465.58
FormulaC31H31NO3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1380548-02-6
SmilesCC(C)(OC1=CC=C(C=C1)OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO2.335mMwithgentlewarming
ethanol2.335mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight465.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.15mL10.74mL21.48mL
5mM0.43mL2.15mL4.3mL
10mM0.21mL1.07mL2.15mL
50mM0.04mL0.21mL0.43mL