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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/NF 1819/5956/10/10 mg
产品编号:5956
市  场 价:¥3500.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$175.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/NF 1819/5956/10/10 mg
商品介绍
Description:PotentandselectiveirreversIBLeMAGLinhibitor;membranepermeableandbrainpenetrant
ChemicalName:(3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveirreversibleMAGLinhibitor(IC50valuesare0.25and7.4nMatrMAGLandhMAGL,respectively).Exhibits389-foldselectivityoverhFAAHandexhibitsminimalbindingatCBreceptors(IC50>10μM).AlleviatessymptomsinaMSinvivomodel.Exhibitsanalgesiceffectsinanacuteinflammatorypainmodelinvivo.Amelioratesneuropathichypersensitivityinducedbyoxaliplatin(Cat.No.2623).DisplayshighmembranepermeABIlityandbrainpenetrant.

TechnicalData

M.Wt463.46
FormulaC24H22FN5O4
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1881244-28-5
SmilesFC1=CC=C([C@@H]2[C@@H](C3=CC=C4OCOC4=C3)N(C2=O)C5CCN(C(N6C=NC=N6)=O)CC5)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO46.35100
ethanol23.1750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight463.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.16mL10.79mL21.58mL
5mM0.43mL2.16mL4.32mL
10mM0.22mL1.08mL2.16mL
50mM0.04mL0.22mL0.43mL