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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PA 1 dihydrochloride/5463/10/10 mg
产品编号:5463
市  场 价:¥3980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PA 1 dihydrochloride/5463/10/10 mg
商品介绍
Description:PhotoswitchableENaCblocker
ChemicalName:3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamidedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Photoswitchableepithelialsodiumchannel(ENaC)blocker(IC50valuesare90and390nMforαβγandδβγENaCs,respectively,inthetransconformation).Switchesconformationfromcistotransat500nmandtranstocisat400nm.BlocksENaCswithgreaterefficacyinthecisconformation,incomparisontothetransconformation,inXenopusoocytesandHEK293tcells.PartiallyblocksδβγENaCsinthetransconformationandexhibitsnearmaximalblockofδβγENaCsinthecisconformation.Amiloridederivative.

TechnicalData

M.Wt482.75
FormulaC18H16ClN9O.2HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
PubChemID121513862
InChIKeyJKZVQNCSFUAMFC-UHFFFAOYSA-N
SmilesO=C(NC(NC2=CC=C(/N=N/C3=CC=CC=C3)C=C2)=N)C1=C(N)N=C(N)C(Cl)=N1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO48.27100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight482.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.07mL10.36mL20.71mL
5mM0.41mL2.07mL4.14mL
10mM0.21mL1.04mL2.07mL
50mM0.04mL0.21mL0.41mL