请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AC 4/5464/10/10 mg
产品编号:5464
市  场 价:¥4900.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$245.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AC 4/5464/10/10 mg
商品介绍
Description:PhotoswitchableTRPV1channelblocker
ChemicalName:1,3,4,5-Tetrahydro-7,8-dihydro-N-[2-[4-[2-[4-(trifluoromethyl)phenyl]diazenyl]phenyl]ethyl]-2H-2-benzazepine-2-carbothioamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PhotoswitchableTRPV1channelblocker(IC50=3.1μM).ActsasanantagoNISTintransconformationduringvoltagegatedactivation.Alsoactsasanantagonistinthecisformationduringcapsaicin-inducedTRPV1currents.Switchesconformationfromcistotransat440nmandtranstocisat360nm.Allowsphotoswitchableantagonistandanagonisttobeappliedatthesametime.

TechnicalData

M.Wt514.56
FormulaC26H25F3N4O2S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1459809-09-6
PubChemID121513863
InChIKeyCOPZFJSJZPCWFD-UHFFFAOYSA-N
SmilesS=C(NCCC3=CC=C(/N=N/C4=CC=C(C(F)(F)F)C=C4)C=C3)N(CCC2)CC1=C2C=C(O)C(O)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO51.46100
water10.2920mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight514.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.94mL9.72mL19.43mL
5mM0.39mL1.94mL3.89mL
10mM0.19mL0.97mL1.94mL
50mM0.04mL0.19mL0.39mL